One-pot strategy to simultaneously achieve heterodehydrocoupling of hydrostannane and reduction of quinoline Heteroatom tin compounds (SSn, OSn, NSn, PSn) composed of heteroatoms S, O, N, P and tin atoms have attracted intense attention due to their wide applications in organic synthesis and pharmaceutical fields. The current methods for synthesis of such compounds, such as metathesis reactions, addition reactions, and free radical reactions, exhibit drawbacks including narrow substrate scope and harsh conditions. Therefore, it is important to develop efficient synthetic systems to construct heteroatom-tin bond.

New horizons for organoboron and organosilicon chemistry with triple elementalization In recent years, organic chemicals containing boron (B) and silicon (Si) have found applications in various fields, including optoelectronics and pharmaceuticals. Moreover, they can also serve as building blocks for complex organic chemicals. As a result, scientists are actively looking for new ways to leverage these versatile chemical tools as well as produce more kinds of organosilicon and organoboron compounds.

Novel synergistic single-atom catalyst approach breaks activity limitation of predecessors The key to chemical reactions is in the name — there needs to be something that causes the chemicals to react to one another. Called a catalyst, this component induces or speeds up reactions in a controlled manner to produce a desired outcome. The catalysts used in several industries are often composed of noble metals, which are not efficient enough to compensate for their high cost. To address this issue for the chemical reaction of adding hydrogen, called hydrogenation, to quinoline, a molecule important in pharmaceutical production, researchers based in China have developed a highly effective catalyst comprising synergistic nanoparticles and single atoms of iridium. They published their approach on March 22 in Nano Research.

Innovation in small molecules: Leading companies in quinoline derivatives as anticancer agents he pharmaceutical industry continues to be a hotbed of innovation, with activity driven by the evolution of new treatment paradigms, and the gravity of unmet needs,

Breakthrough photochemistry method opens doors to new drugs March 26, 2021 -- Medicinal chemists have succeeded in converting several classes of flat nitrogen-containing molecules into 3D structures that could form the basis for new drug candidates. The methods, published in Science on March 26, detail over 100 examples of the broad applicability of overcoming the conversion barrier through light-mediated energy transfer.